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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteronegel alone. This was a prospective cohort study with 904 older men (mean 66.6 years, age 79), of whom 581 (55%) completed the study. All of the participants were taking testosterone for muscle gains and 638 (76%) were taking testosterone for an enlarged prostate. They were not taking hormone replacement therapy. There was no difference between groups in regard to age, height, body weight, total cholesterol, triglycerides, total cholesterol:HDL cholesterol ratio, fasting glucose, fasting insulin, fasting glucose (AUC) and 2H 2 O. All men had an energy requirement between 20 and 3300 kcal/day (range: 1300 to 2380 kcal/day). Blood pressure, plasma lipids, inflammatory markers, muscle performance, inflammation markers and prostate size were not different between the different groups but a greater increase in mean weight, total cholesterol (P=.014) and triglycerides (P=.025) was seen in the Weight Watchers group (Table 1). There was no difference in bone mineral density between the groups when compared with the placebo group. There was no change in mean bone mineral density in the Weight Watchers group when compared with the two groups which received testosterone gel alone (Figs 1c and 2c). Table 1. Group Number of participants (n) P-value2 Energy requirement (kJ/day) Mean (SD) Age (years) Mean (SD) Height (cm) Mean (SD) Muscle Mass (kg) Mean (SD) Fat Mass (kg) Mean (SD) Lean Body Mass (kg) Mean (SD) Total Body Mass (kg) Mean (SD) Total Femur (kg) Mean (SD) Total Limbs (kg) Mean (SD) BMI % Mean (SD) Body Fat % Mean (SD) Total Body Fat (%) Mean (SD) Bone Minerals (%) Mean (SD) Bone mineral density P-value2a Men (n=541) Age (years) 69.5 (6.1) 66.6 (2.1) <.001 66.6 (5.3) 65.0 (5.6) 65.4 (5.8) 70.2 (6.5) 0.0007 (5.3) 72.7 (7.8) <.001 .03 0.0007 (5.5) 0.0006 (5.6) 0.0007 (5.6) <.001 .073 0 Related Article:

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